Sarcomatoid Renal Cell Carcinoma Treatment

Sarcomatoid transformation in renal cell carcinoma so called sacromatoid rcc srcc is associated with an aggressive behavior and a poor prognosis.

Sarcomatoid renal cell carcinoma treatment.

Treatment protocols for renal cell carcinoma are provided below including treatment of localized and advanced disease and recommendations for patients with predominantly clear cell carcinoma and those with predominantly non clear cell carcinoma. Sarcomatoid kidney cancer occurs in only 5 percent of all kidney cancer cases. Renal cell carcinoma rcc is highly resistant to chemotherapy. 2 analyzed 72 cytotoxic chemotherapeutic agents used singly or in a limited number of 2 drug combinations in 3502 patients and found reports of objective responses complete cr and partial remissions pr in only 197 5 6 of these patients 95 confidence interval ci 4 8 6 4.

The therapeutic approach for renal cell carcinoma is guided by the probability of cure which i. The presence of sarcomatoid differentiation in a patient with renal cell carcinoma portends a much worse prognosis than those without it. Volume 15 pages 287 to91. Current therapeutic approaches are largely ineffective.

The earlier it s detected the greater your chance for effective treatment. The tissue from his removed kidney showed a rare but aggressive form of kidney cancer known as sarcomatoid kidney cancer. Clear cell areas are golden in color due to cellular lipid accumulation while sarcomatoid foci are white. Sorafenib after combination therapy with gemcitabine plus doxorubicine in patients with sarcomatoid renal cell carcinoma.

Learn about the staging criteria and get the. Recent studies looking into the genomic and molecular characterization of srccs have provided. Awareness of the imaging characteristics of sarcomatoid renal cell carcinoma is important as this diagnosis may alter treatment plans and follow up protocols. 1 in 1993 yagoda et al.

Volume 23 issue 7 pages 430 7. Sarcomatoid renal cell carcinoma v arnoux and others prog urology 2013. Sarcomatoid renal cell carcinoma arising from a clear cell renal cell carcinoma lower left. Many kinds of cancer are treated with radiation or chemotherapy or sometimes both these treatments usually don t work well for renal cell carcinoma.

A prospective evaluation m staehler and others european journal of medical research 2010.